IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions
نویسندگان
چکیده
منابع مشابه
IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells.
IL-23 is a recently discovered heterodimeric cytokine that shares biological properties with proinflammatory cytokines. The biologically active heterodimer consists of p19 and the p40 subunit of IL-12. IL-23 has been shown to possess biological activities on T cells that are similar as well distinct from those of IL-12. We have constructed single-chain IL-23 and IL-12 fusion proteins (IL-23-Ig ...
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ژورنال
عنوان ژورنال: Cells
سال: 2020
ISSN: 2073-4409
DOI: 10.3390/cells9102184